InterPAD - DETAILS

4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en- 6-one, cocculine, cucoline, cucoline hydrochloride, cucoline, hydrochloride, cuculine, kukoline, morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9alpha,13alpha,14alpha)-, morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride (1:1), (9alpha,13alpha,14alpha)-, NSC-76021, sinomenin hydrochloride, sinomenine, sinomenine A bismethyliodide, sinomenine hydrochloride

No.	Title	Href
1	Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma. World J Gastroenterol. 2013 Dec 7;19(45):8292-300. doi: 10.3748/wjg.v19.i45.8292.	`Click`
2	Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis. J Chemother. 2023 Jul;35(4):357-366. doi: 10.1080/1120009X.2022.2111490.	`Click`

No.

Title

Href

Cooperative inhibitory effect of sinomenine combined with 5-fluorouracil on esophageal carcinoma. World J Gastroenterol. 2013 Dec 7;19(45):8292-300. doi: 10.3748/wjg.v19.i45.8292.

Click

Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis. J Chemother. 2023 Jul;35(4):357-366. doi: 10.1080/1120009X.2022.2111490.

Click

Name	Sinomenium acutum
PubChem CID	5459308
Molecular Weight	329.4g/mol
Synonyms	4-hydroxy-3,7-dimethoxy-17-methylmorphin-7-en- 6-one, cocculine, cucoline, cucoline hydrochloride, cucoline, hydrochloride, cuculine, kukoline, morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9alpha,13alpha,14alpha)-, morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, hydrochloride (1:1), (9alpha,13alpha,14alpha)-, NSC-76021, sinomenin hydrochloride, sinomenine, sinomenine A bismethyliodide, sinomenine hydrochloride
Formula	C₁₉H₂₃NO₄
SMILES	CN1CCC23CC(=O)C(=CC2C1CC4=C3C(=C(C=C4)OC)O)OC
InChI	1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1
InChIKey	INYYVPJSBIVGPH-QHRIQVFBSA-N
CAS Number	115-53-7
ChEMBL ID	CHEMBL248095
ChEBI ID	CHEBI:9163
Drug Bank ID	DB16892
KEGG ID	C09643
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	QingFengTeng
Use Part	Cane
Habitat	ZheJiang, JiangSu, HuBei, HuNan
Flavor	Pungent; Bitter
Meridian Tropism	Liver; Spleen
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Ranunculales 　　　　-->Family: Menispermaceae 　　　　　-->Genus: Sinomenium 　　　　　　-->Species: Sinomenium acutum

Pair Name	Sinomenium acutum, Fluorouracil
Partner Name	Fluorouracil
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Biological Phenomena	Induction-->Mitochondria-mediated apoptosis
Gene Regulation	Up-regulation	Expression	BAX	hsa581
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
In Vitro Model	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens (Human)	CVCL_6898
In Vivo Model	Esophageal carcinoma tumors were established in male BALB/c nude mice (4-6 wk, Laboratory Animal Central of Wuhan University) by serial subcutaneous transplantation of Eca-109 cells (1×10⁷ cells/mouse).
Result	The combined effects of SIN and 5-FU on esophageal carcinoma were superior to those of the individual compounds, and the drug combination did not increase the side effects of chemotherapy.

Pair Name	Sinomenium acutum, Cisplatin
Partner Name	Cisplatin
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Gene Regulation	Down-regulation	Expression	MIR200A	hsa406983
In Vitro Model	A-549	Lung adenocarcinoma	Homo sapiens (Human)	CVCL_0023
Result	This study revealed a new molecular mechanism for the sinomenine-promoted cisplatin sensitization, contributing to investigating the sinomenine-based therapeutic agents against chemoresistant NSCLC.